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Det er viktig at sykepleiere er klar around dette når de snakker med pasienter som sier «jeg forsøkte å slutte med zopiklon, Guys fikk ikke sove». Da må sykepleierne vite litt om farmakologi og hva brå seponering gjør. Du må også ha forsøkt minst tre forebyggende legemidler mot migrene. Behandlingen med disse må ha vært uten tilstrekk